The aim of the REACTION project was to develop an integrated ICT platform that supports improved long term management of diabetes based on wearable, continuous blood glucose monitoring sensors and automated closed-loop delivery of insulin. The REACTION platform presents an interoperable peer-to-peer communication platform based on Service Oriented Architecture (SoA) using cloud-enabling midddleware. It will feature a Model Driven Application Development environment based on extensive use of dynamic ontologies. The REACTION platform provides integrated, professional, management and therapy services to diabetes patients in different healthcare regimes across Europe, including 1) professional decision support for in-hospital environments, 2) safety monitoring for dosage and compliance, 3) long term management of outpatients in clinical schemes, 4) care of acute diabetic conditions and 5) support for self management and life-style changes for diabetic patients.