The aim of the MobiGuide project is to develop an intelligent decision-support system for patients with chronic illnesses. The system accompanies the patients wherever they go and helps them and their care providers in managing their illness, whether they are at home, at work, out and about or travelling abroad on holiday or for business. The MobiGuide project develops an intelligent decision-support system for patients with chronic illnesses, such as cardiac arrhythmias, diabetes, and high blood pressure. The patients wear sensors that can monitor biosignals (e.g., heart rate, blood pressure); the signals are transmitted to their Smartphone and from there to a powerful "backend" computer. The MobiGuide decision-support tools, which have access also to the patient's' historical clinical data, such as their hospital records, analyse the data, alert the patient about actions that should be taken, ask the patient questions, in the case that additional information is needed, and make recommendations regarding lifestyle changes or contacting care providers. All recommendations regarding therapy are transmitted to the patients' care providers. The recommendations are based on evidence- based, state-of-the-art clinical guidelines. During the project we intend to focus on the clinical conditions: atrial fibrillation, gestational diabetes and gestational hypertension.